Long-term use of melatonin supplements to support sleep may …
Nov 3, 2025 · Melatonin supplements are promoted and marketed as a safe sleep aid; however, data demonstrating their long-term cardiovascular safety are lacking, which prompted the …
Melatonin: beyond circadian regulation - exploring its diverse ...
Aug 1, 2025 · Melatonin, first isolated and identified in 1958, is primarily synthesized in the pineal gland of mammals and regulated by the suprachiasmatic nucleus (SCN) of the hypothalamus …
Melatonin - StatPearls - NCBI Bookshelf
Feb 9, 2024 · Melatonin regulates the body's sleep-wake cycles by interacting with the suprachiasmatic nucleus of the hypothalamus and the retina. The best-known purpose of …
Melatonin, Melatonin Receptors and Sleep: Moving Beyond …
Oct 14, 2024 · This review examines research on the multifaceted role of melatonin in sleep regulation, focusing on selective ligands targeting MT1 and MT2 receptors, as well as studies …
Melatonin: What It Is, What It Does & How It Works - Cleveland Clinic
Melatonin helps control your circadian rhythm. This is your sleep-wake cycle that happens automatically about every 24 hours. Melatonin helps your body get ready to fall asleep. It’s not …
What is the Role of Melatonin in Sleep Regulation?
May 10, 2024 · The pineal gland, which is situated in the midline of the brain, analyses the current state of the environmental light-dark cycle and regulates the production and secretion of …
Melatonin in the Regulation of Sleep and Biological Rhythms
Oct 1, 2024 · Melatonin, as a hormone of the circadian system, plays an important role in regulating physiological functions and facilitating adaptation to regular environmental changes.
Melatonin’s role in the timing of sleep onset is conserved
Nov 1, 2024 · Our findings demonstrate that melatonin’s role in sleep is evolutionarily conserved, effectively challenging the argument that melatonin cannot play a major role in sleep regulation …
Circadian Rhythm and Melatonin: How They Regulate Sleep
Jul 27, 2025 · The relationship between the circadian rhythm and melatonin regulates the body’s sleep-wake cycle. Environmental cues, particularly light, are detected by specialized cells in …
New perspectives on the role of melatonin in human sleep
The SCN-activated, light-inhibited production of melatonin conveys the message of darkness to the clock and induces night-state physiological functions, for example, sleep/wake blood …