A short overview of dual targeting HDAC inhibitors - PMC
While, dual targeting HDAC inhibitors have the potential to overcome the aforementioned issues and reduce the occurrence of side effects, making the development of this class of compounds …
HDAC and PI3K dual inhibitors in the treatment of cancers: …
HDAC inhibitors have been shown to reverse the abnormal acetylation status in cancer cells, leading to the reestablishment of cellular acetylation homeostasis and the restoration of …
Next-Generation HDAC Inhibitors: Advancing Zinc-Binding Group …
Dec 15, 2025 · Histone deacetylases (HDACs) are pivotal epigenetic regulators that control gene expression, cell proliferation, and differentiation, and their dysregulation is closely associated …
Mechanisms of HDACs in cancer development - Frontiers
Apr 7, 2025 · Based on this, HDAC inhibitors (HDACis), as novel epigenetic-targeted therapeutic agents, have demonstrated significant antitumor potential by inducing cell cycle arrest, …
Histone deacetylase (HDAC) Inhibitors Database
Dec 21, 2024 · Histone deacetylase inhibitors (HDACIs) are emerging as a new class of potential anticancer agents and have been shown to induce differentiation, cell-cycle arrest, and …
HDAC and PI3K dual inhibitors in the treatment of cancers: …
This review delves into the dual-target inhibitors of HDAC and PI3K, exploring their design principles and pharmacological properties. This article covers the literature up to October …
A short overview of dual targeting HDAC inhibitors
Dec 8, 2024 · This insight has led to the realization that developing dual-targeting inhibitors, such as HDAC/BRD4 and HDAC/JAK, is feasible to overcome drug resistance in solid tumors.
Recent progress in synthetic strategies to develop potent, HDAC8 ...
Dec 1, 2025 · Herein, we discuss the topology of the HDAC8 active site in the context of inhibitor design, and we present recent progress in the discovery of potent, HDAC8-selective small …
Frontiers | The role of HDAC3 in inflammation: mechanisms and ...
Jul 10, 2024 · Despite some conflicting reports, the selective inhibition of HDAC3 has been demonstrated to play a beneficial role in various inflammatory pathologies. The selective …
Targeting histone deacetylases for cancer therapy: Trends and ...
Feb 18, 2023 · Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and progression. As promising anticancer targets, HDACs have gained a great …