Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.

Rats exhibit significant recovery of locomotor function following incomplete spinal cord injuries, albeit with altered gait expression and reduced speed and stepping frequency. These changes likely ...

Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.

The chirality of tissues and organs is essential for their proper function and development. Tissue-level chirality derives from the chirality of individual cells that comprise the tissue, and cellular ...

Here, we address this question further by combining large-scale electrophysiological recordings, to characterize the functional connectivity of developing neuronal networks in vitro, with a generative ...

A compound found in fungal cell walls can reprogram immune cells in the lungs, potentially worsening inflammation during infections.

An analytical approach increases spatiotemporal resolution, optimizes real-time, in vivo detection of Met- and Leu-enkephalin, and provides novel insight into the relationship between Met- and ...

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

This useful study presents a biologically realistic, large-scale cortical model of the rat's non-barrel somatosensory cortex, investigating synaptic plasticity of excitatory connections under varying ...

Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.