Hydrogen sulfide (H 2 S)-based mitochondrial energy metabolism blockade is an attractive tumor therapeutic modality. However, it is limited owing to metabolic plasticity, which allows tumors to shift ...

Researchers show that pharmacological activation of hypoxia signaling improves metabolism, limits fat accumulation, and ...

Experts at Cincinnati Children's have uncovered striking metabolic differences in people with Fanconi anemia (FA), a rare genetic disorder that causes bone marrow failure and dramatically increases ...

Obesity is widely known for increasing the risk of diabetes and cardiovascular disease, but its damaging effects on the ...

Digestive tract tumors are malignant diseases characterized by high aggressiveness, heterogeneity and metabolic abnormalities. Heterogeneity and drug resistance among tumors pose a serious challenge ...

Preclinical research across multiple cancer types now shows that the NAD+ salvage pathway, the same biological mechanism targeted by popular anti-aging supplements like nicotinamide mononucleotide ...