TRAFs have important roles in intracellular signal transduction of many receptor families such as the TNF receptor superfamily, the IL-1 receptors (IL-1R), the Toll-like receptors (TLR), T-cell ...
Receptor oligomerization in the form of homodimers — for example, erythropoietin (EPO) receptor (EPOR), growth hormone receptor (GHR) or hetero-oligomers (for example, IL-2R) — is the key event in ...
What is dimerization? It is a process where two molecules of similar chemical composition come together to form a single polymer known as a dimer. Where does dimerization occur? It happens throughout ...
Phase I Pharmacokinetic and Pharmacodynamic Study of Weekly 1-Hour and 24-Hour Infusion BMS-214662, a Farnesyltransferase Inhibitor, in Patients With Advanced Solid Tumors Twenty-one patients received ...
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