Now, however, a surprising discovery about BH4 will likely rekindle interest in the once-promising pathway and could have profound implications for treating autoimmunity and cancer. In today's Nature, ...

Apoptosis is an essential physiological process that leads to the selective elimination of cells in metazoans, and it is involved in a variety of biological events. The mitochondria often play a ...

From a failed pain drug, a protein called ‘BH4’, was recently discovered to have surprising implications in the treatment of autoimmunity and cancer. It was specifically found that BH4 functions as a ...

A new study has found an old antipsychotic drug blocks a signaling pathway that has been linked to chronic neuropathic pain. The surprising findings not only point to novel future treatments for pain ...

A team of scientists in Vienna, including an Irish researcher, has made a substantial breakthrough that could help us fight cancer in a new way. The foundational work by the winners of this year’s ...

Researchers have identified a molecule sent by fat cells to the fly brain that senses when they have had enough food and inhibits feeding. Researchers have identified a molecule sent by fat cells to ...

BioMarin Pharmaceutical Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease Subjects Show Improvement in Endothelial Dysfunction ...